Flavonoids – a group of polyphenolic substances are naturally present in vegetables, fruits, seeds and beverages such as tea and wine. Studies have shown that flavonoid intake is inversely correlated with mortality from coronary heart diseases and myocardial infaction. The effect of kolaviron (a flavonoid complex) extracted from garcinia kola seeds on the plasma and PMF phospholipids and proteins and on the organ weights (lungs, kidneys, heart, spleen and liver) of rats administered with cholesterol, five times a week, for eight consecutive weeks was investigated. The phospholipid levels was relatively stable in both the plasma and the PMF.There was no significant difference (p