Background: This study evaluated the hematological changes in Channa striatus (120 ± 3.5 g) intramuscularly administered with Aeromonas hydrophila. The experiment consisted of two treatments in triplicates: non-injected control fish; fish injected with 2.4 x 108 CFU/mL of A. hydrophila. Forty-eight hours after injection, the fish were anesthetized and the blood collected. The hematological parameters included red blood corpuscles (RBCs) count, white blood cells (WBCs) count, packed cell volume (PCV), differential count of WBCs, the derived blood indices of mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular
haemoglobin concentration (MCHC) were studied in the experimental and control fish.
Results: Fish injected with 2.4 x 108 CFU/mL of A. hydrophila showed a higher MCV value than control fish. White blood cells and lymphocytes numbers increased significantly in fish injected with A. hydrophila when compared to non-injected control. PCV also increased in fish injected with 2.4 x 108 CFU/mL of A. hydrphila.
Hematological data were analyzed with SPSS 7.5 for Windows by using one way analysis of variance.

